Divergent influences of the locus coeruleus on migraine pathophysiology

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Effects of bilateral lesion of the locus coeruleus on the sleep-wake cycle in the rat

Introduction: Noradrenergic cells in LC participate in the process of cortical activation and behavioral arousal. The evidence suggests that locus ceoruleus (LC) plays an important role in the sleep-wake cycle. The aim of this study was stereological estimation of cavity caused by lesion and assessment of sleep stages after bilateral lesion of the LC. Materials and Methods: Male Wistar rats we...

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The effect of morphine on some electrophysiological parameters of paragigantocellularis and locus coeruleus nuclei interconnections

As one of the most important diffused brain modulatory systems, the nucleus locus coeruleus (LC) receives most of its afferents from the nucleus paragigantocellularis (PGi) and plays a major role in the control of drug dependence and some emotional and exciting states. For detailed investigation of the effect of morphine on relationship between these two brain stem nuclei, the activity of the r...

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The effect of morphine on some electrophysiological parameters of paragigantocellularis and locus coeruleus nuclei interconnections

As one of the most important diffused brain modulatory systems, the nucleus locus coeruleus (LC) receives most of its afferents from the nucleus paragigantocellularis (PGi) and plays a major role in the control of drug dependence and some emotional and exciting states. For detailed investigation of the effect of morphine on relationship between these two brain stem nuclei, the activity of the r...

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The effects of locus coeruleus electrical stimulation on brain waves of morphine dependent rats

Introduction: Opiates cause dependency via affect on central nervous system. Locus coeruleus nucleus is a main group of noradrenergic neurons in the brain that plays an important role in the expression of opioid withdrawal signs. During opioid withdrawal, brain waves change in addition to physical and behavioral signs. In this study, we examined the effects of locus coeruleus electrical sti...

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Pathophysiology of the human locus coeruleus complex in fetal/neonatal sudden unexplained death.

OBJECTIVES We investigated the locus coeruleus complex in the brainstems of 78 subjects aged from 24 gestational weeks to 8 postnatal months, who died of unknown (sudden unexplained fetal and infant deaths) and known causes (controls). The goals of this study were: (1) to obtain basic information about the morphology of the locus coeruleus complex and the expression of different biological par...

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ژورنال

عنوان ژورنال: Pain

سال: 2018

ISSN: 0304-3959,1872-6623

DOI: 10.1097/j.pain.0000000000001421